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MEK inhibition alleviates macrophage overactivation without compromising the efficacy of CAR-T-cell therapy

Hui Li1,2, Youming Wang1,2, Yingxiang Wang1

  • 1Department of Hematology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

British Journal of Haematology
|February 18, 2026
PubMed

Keywords:
CAR‐T therapyMEK inhibitorcytokine release syndromemacrophagesecondary haemophagocytic lymphohistiocytosis

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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.