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Morphology-adaptive Au-Ag nanowire elastronics for integrated FlexoSERS and bioelectrical sensing
Heng Zhang1,2, Yi Chen1,2, Gangsheng Chen1
1State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, China.
Science Advances
|February 18, 2026
Summary
This study presents a flexible gold-silver nanowire platform for advanced optical-electrical sensing. The adaptable elastronic system enables high-performance wearable health monitoring and human-machine interfaces.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Developing adaptable electronic platforms for multimodal sensing is crucial for advanced health monitoring.
- Existing wearable sensors often lack the mechanical flexibility and multimodal capabilities required for comprehensive physiological tracking.
Purpose of the Study:
- To introduce a morphology-adaptive gold-silver nanowire elastronic platform for diverse geometries and multimodal optical-electrical sensing.
- To demonstrate the platform's utility in both surface-enhanced Raman spectroscopy (SERS) and bioelectrical signal detection.
Main Methods:
- Fabrication of vertically aligned Au-Ag nanowire arrays on 1D, 2D, and 3D substrates using template-guided growth.
- Characterization of the platform's performance as a FlexoSERS interface under strain and cyclic loading.
- Evaluation of the platform as dry bioelectrical electrodes for electrocardiogram (ECG) and electromyogram (EMG) monitoring.
Main Results:
- Achieved high sensitivity and uniformity (RSD = 7.2%) for SERS detection on 2D elastic films, with stable signals under 100% strain and after 2500 cycles.
- Demonstrated stable ECG and EMG monitoring on 3D porous sponges with long-term reliability.
- Successfully classified sleep and wake states using deep learning analysis of continuous ECG data.
- Captured subtle motor activities via EMG signals, including finger bending and typing.
Conclusions:
- The morphology-adaptive Au-Ag nanowire platform offers a robust foundation for next-generation wearable health monitors.
- The integration of strain-tolerant FlexoSERS and reliable bioelectrical sensing across various substrates enables advanced applications.
- This scalable route supports intelligent sleep evaluation and improved human-machine interfaces.
