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Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy
Published on: July 25, 2022
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Large-area low-noise resonant photodetector for high-sensitivity stimulated Raman scattering spectroscopy and imaging
Optics Express
|February 18, 2026
Summary
We developed a low-noise amplifier for large photodiodes used in stimulated Raman scattering (SRS) detection. This new design enables highly sensitive measurements for quantum optics and live cell imaging.
Area of Science:
- Optics and Photonics
- Biomedical Imaging
- Quantum Optics
Background:
- Stimulated Raman Scattering (SRS) detection requires sensitive amplifiers for large-area photodiodes.
- High junction capacitance in large photodiodes presents challenges for amplifier stability and noise performance.
- Conventional detectors often saturate under high optical power, limiting characterization of quantum states.
Purpose of the Study:
- To present a novel low-noise compensated tuned amplifier (cTAMP) architecture.
- To optimize the amplifier for large-area photodiodes in SRS detection.
- To demonstrate its capability for high-sensitivity quantum optics and biomedical imaging applications.
Main Methods:
- Integrated a tunable RLC feedback network with a matching compensation inductor.
- Designed the amplifier to overcome high junction capacitance of large photodiodes (10x10 mm^2).
- Configured a detector with a 20 MHz center frequency and 1 MHz bandwidth.
Main Results:
- Achieved an output-referred noise floor of 31 nV/√Hz.
- Enabled shot-noise-limited linear operation from 0.1 mW to 36 mW optical power.
- Demonstrated wide dynamic range and low noise for characterizing high-power squeezed states and enabling ultrafast SRS microscopy.
Conclusions:
- The cTAMP-based detector offers a versatile platform for high-sensitivity quantum optics and biomedical imaging.
- The design facilitates biocompatible SRS microscopy with milliwatt-level excitation for live cell imaging.
- Potential for extension to other modulation-based optical measurements exists.
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