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Updated: Feb 20, 2026

Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy
Published on: July 25, 2022
Large-area low-noise resonant photodetector for high-sensitivity stimulated Raman scattering spectroscopy and imaging
Abstract:
We report a low-noise compensated tuned amplifier (cTAMP) architecture optimized for large-area photodiodes in stimulated Raman scattering (SRS) detection. By integrating a tunable RLC feedback network with a matching compensation inductor, the design simultaneously achieves resonance enhancement and amplifier stability despite the high junction capacitance of a 10 × 10 mm2 photodiode. As a proof of concept, a detector configured for 20 MHz center frequency and 1 MHz bandwidth exhibits an output-referred noise floor of 31nV/Hz, enabling shot-noise-limited linear operation from 0.1 mW up to 36 mW optical power under ∼50 μs time constant in the near-IR region. This wide dynamic range and low noise performance allow faithful characterization of high-power squeezed states that saturate conventional detectors, as verified in photon-number squeezing experiments. In addition, the detector facilitates biocompatible ultrafast SRS microscopy with milliwatt-level excitation, supporting hyperspectral live cell imaging without compromising sensitivity. These results establish the cTAMP-based detector as a versatile platform for high-sensitivity quantum optics and biomedical imaging, with potential for extension to other modulation-based optical measurements.
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