Associations Between Nutritional Status, Sleep Quality, and Clinical Factors in Patients With Metastatic Prostate...

Area of Science:

• Oncology
• Nutritional Science
• Sleep Medicine

Background:

• Metastatic prostate cancer (mPC) patients frequently experience malnutrition and poor sleep quality, which are often overlooked.
• These conditions can significantly impact patient outcomes and quality of life.

Purpose of the Study:

• To investigate the relationship between nutritional status, sleep quality, and clinical outcomes in men with mPC.
• To identify factors associated with poor sleep quality in this patient population.

Main Methods:

• A cross-sectional study involving 91 men with stage IV prostate cancer.
• Nutritional status assessed using Subjective Global Assessment (SGA); sleep quality assessed using Pittsburgh Sleep Quality Index (PSQI).
• Clinical parameters, laboratory values (albumin, hemoglobin, CRP), and quality-of-life scores were analyzed. Multivariable logistic regression identified predictors of poor sleep.

Main Results:

• 65.9% of patients reported poor sleep quality, with higher prevalence in malnourished individuals (P < .001).
• Worse nutritional status correlated with lower albumin and hemoglobin, higher CRP, poorer performance status, and reduced quality of life (P < .001).
• Independent predictors of poor sleep included elevated CRP, lower hemoglobin, and poorer nutritional status (SGA C vs. A).

Conclusions:

• Malnutrition and systemic inflammation are strongly associated with impaired sleep quality and reduced quality of life in mPC.
• Nutritional screening and targeted interventions are crucial for supportive care in mPC patients.
• Optimizing nutritional status and managing sleep disturbances can enhance patient well-being.