Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

479
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
479
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

328
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
328
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

710
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
710

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary Artery Bypass Grafting versus Percutaneous Coronary Intervention for Stable Multivessel Coronary Disease in the Current Era.

The Annals of thoracic surgery·2026
Same author

Bioprosthetic versus mechanical surgical aortic valve replacement in patients ≥65 years of age.

JTCVS open·2026
Same author

Temporizing Balloon Aortic Valvuloplasty Before Transcatheter Aortic Valve Replacement in Decompensated Severe Aortic Stenosis.

The American journal of cardiology·2026
Same author

A 'Target Trial Emulation' of Prehospital Sublingual Nitroglycerin Administration for Suspected Acute Coronary Syndrome.

Prehospital emergency care·2026
Same author

Genetic Syndromes Do Not Affect Survival but Increase Morbidity in Neonates with Symptomatic Tetralogy of Fallot.

The Journal of pediatrics·2026
Same author

Unveiling the Potential of <i>N</i>-Hydroxyphthalimide with Zn in Alkylative Dearomatization of <i>N</i>-Alkylpyridinium Salts.

The Journal of organic chemistry·2026

Related Experiment Video

Updated: Feb 20, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

630

Young Transcatheter Aortic Valve Implantation: Shifting Risk and Outcomes.

J Hunter Mehaffey1, Vikrant Jagadeesan2, Michael Bowdish3

  • 1Department of Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown, WV 26501, United States.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|February 18, 2026
PubMed
Summary

Younger patients (≤65 years) undergoing Transcatheter Aortic Valve Implantation (TAVI) are typically low surgical risk. Careful heart team evaluation is crucial for these patients, considering TAVI

Keywords:
TAVIoutcomesriskyoung

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.5K
Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

12.3K

Related Experiment Videos

Last Updated: Feb 20, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

630
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.5K
Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

12.3K

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Health Services Research

Background:

  • Transcatheter Aortic Valve Implantation (TAVI) is increasingly used in patients aged 65 and younger.
  • These younger patients are often presumed to be at high surgical risk with limited life expectancy.

Purpose of the Study:

  • To evaluate the predicted risk, procedural outcomes, longitudinal results, and cost of TAVI in patients 65 years or younger.
  • To stratify TAVI outcomes based on predicted mortality risk in this demographic.

Main Methods:

  • Analysis of 6,921 patients aged 65 or younger who received TAVI between 2017 and 2024.
  • Utilized a simulated Society of Thoracic Surgeons risk model incorporating the Fried frailty index to assess predicted mortality risk (AUC=0.850).

Main Results:

  • The median age was 60 years, with 81.3% of procedures being elective and 9.1% involving bicuspid aortic valves.
  • The average predicted mortality risk was 4.3%, with 66.2% of patients having a predicted risk below 4%.
  • 30-day mortality was 0.7%, with notable complication rates including stroke (1.0%) and new permanent pacemaker (4.1%). 5-year survival was 88% for low/intermediate risk and 78% for high-risk patients.

Conclusions:

  • The majority of contemporary patients aged 65 or younger receiving TAVI outside current guidelines present with low surgical risk.
  • Findings underscore the necessity for thorough heart team discussions for younger patients undergoing aortic valve replacement (AVR), considering TAVI's cumulative risks.