Related Experiment Video
Updated: Feb 20, 2026

Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro
Published on: January 11, 2017
The Lipid Interactome: an interactive and open access platform for exploring cellular lipid-protein interactions.
Gaelen Guzman1, André Nadler2, Frank Stein3
1Department of Molecular Immunology & Immunology, Oregon Health & Science University, Portland, OR 97239, United States.
The Lipid Interactome database centralizes lipid interactome data, enabling systematic exploration of lipid-protein interactions. This resource enhances understanding of lipid functions in cellular systems by harmonizing diverse study findings.
Area of Science:
- Biochemistry
- Molecular Biology
- Proteomics
Background:
- Lipid-protein interactions are crucial for cellular signaling and membrane dynamics.
- Systematic characterization of these interactions is challenging due to lipid properties.
- Advances in functionalized lipid probes enable proteomics-based identification of interacting proteins.
Purpose of the Study:
- To address the lack of centralized, harmonized lipid interactome data.
- To provide a structured, interactive web portal for exploring lipid-protein interactions.
- To facilitate systematic comparison and integration of lipid interactome studies.
Main Methods:
- Development of the Lipid Interactome web portal.
- Adherence to FAIR data principles (Findable, Accessible, Interoperable, Reusable).
- Standardized data formatting and interactive visualizations for cross-study comparisons.
Main Results:
- Consolidation and curation of lipid interactome proteomics data from multiple studies.
- A centralized resource for exploring protein-binding partners of bioactive lipids.
- Enabling unprecedented specificity and resolution in identifying lipid-interacting proteins.
Conclusions:
- The Lipid Interactome database serves as a critical tool for deciphering lipid functions.
- It promotes systematic exploration and understanding of lipid-protein interactions.
- The portal enhances reusability and accessibility of lipid interactome research data.
More Related Videos
Related Concept Videos
Protein-protein Interfaces
Protein-Protein Interfaces
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks
Lipids as Anchors
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

