Related Experiment Video
Updated: Feb 20, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
Orbital Emphysema From Chronic Intranasal Cocaine Use
Gio Manguerra1, Wesley Eilbert1
1Department of Emergency Medicine, University of Illinois, College of Medicine, Chicago, Illinois.
Background:
Chronic intranasal cocaine use can cause destruction of sinonasal osteocartilaginous structures. Communication between the paranasal sinuses and the orbit may result in orbital emphysema.
Case Report:
A 47-year old man with a history of chronic intranasal cocaine use presented to the emergency department with two months of recurrent episodes of right eye proptosis exacerbated by nose blowing. Maxillofacial computed tomography revealed a large amount of right orbital emphysema, with obvious destruction of the lateral border of the right ethmoid sinus. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Orbital emphysema requires specific treatment depending on its level of severity. Damage to the midface sinuses from chronic intranasal cocaine use may result in orbital emphysema.
Related Concept Videos
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
Nose and Nasal Cavity
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

