Related Experiment Video
Updated: Feb 20, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
Orbital Emphysema From Chronic Intranasal Cocaine Use
Gio Manguerra1, Wesley Eilbert1
1Department of Emergency Medicine, University of Illinois, College of Medicine, Chicago, Illinois.
Chronic intranasal cocaine use can lead to orbital emphysema, causing eye proptosis. Emergency physicians must recognize this condition and its link to sinonasal structure damage for appropriate management.
Area of Science:
- Otolaryngology
- Ophthalmology
- Emergency Medicine
Background:
- Chronic intranasal cocaine use can destroy sinonasal osteocartilaginous structures.
- This destruction can create abnormal pathways between sinuses and the orbit.
- Such communication may lead to orbital emphysema.
Purpose of the Study:
- To highlight the association between chronic intranasal cocaine use and orbital emphysema.
- To inform emergency physicians about this potential complication.
- To emphasize the need for prompt diagnosis and management.
Main Methods:
- Case report of a 47-year-old male with a history of chronic intranasal cocaine use.
- Presentation with recurrent right eye proptosis, exacerbated by nose blowing.
- Maxillofacial computed tomography (CT) revealed right orbital emphysema and ethmoid sinus destruction.
Main Results:
- The patient exhibited significant right orbital emphysema.
- CT scan demonstrated destruction of the lateral border of the right ethmoid sinus.
- Symptoms were directly linked to cocaine-induced sinonasal damage.
Conclusions:
- Orbital emphysema is a potential consequence of chronic intranasal cocaine use.
- Damage to midface sinuses from cocaine abuse can result in orbital emphysema.
- Emergency physicians must be aware of this association for timely diagnosis and treatment.
Related Concept Videos
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
Nose and Nasal Cavity
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

