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Association between gout and cardiovascular disease: A register-based cohort study

Haolong Pei1, Li He2, Shuang Wang3

  • 1School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China; Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen 518055, China; Tongji University School of Medicine, Tongji University, Shanghai 200331, China.

Progress in Cardiovascular Diseases
|February 18, 2026
PubMed

Insights

Gout patients face a higher risk of cardiovascular disease (CVD) incidence. This study highlights the need for better gout management to reduce CVD burden, especially in women and younger adults.

Area of Science:

  • Cardiology
  • Rheumatology
  • Public Health

Background:

  • Gout and cardiovascular disease (CVD) are prevalent globally.
  • Limited data exist on the gout-CVD association in Chinese populations.

Purpose of the Study:

  • To investigate the association between gout and incident CVD risk.
  • To analyze CVD risk in a large Chinese cohort.

Main Methods:

  • A register-based cohort study in Shenzhen, China (2016-2022).
  • Included 230,339 gout patients and 1,055,509 matched controls.
  • Used Cox regression to analyze CVD incidence (IHD, stroke, HF).

Main Results:

  • Gout patients had a 27% higher risk of total CVD incidence (HR: 1.27, 95% CI: 1.24-1.29).
  • Incidence rates were 9.82 per 1000 person-years for gout patients vs. 6.24 for controls.
  • Women and younger adults (18-44 years) with gout showed higher relative CVD risks.

Conclusions:

  • Gout is significantly associated with increased incident CVD risk.
  • Effective prevention and management strategies are crucial to reduce CVD burden in gout patients.
Abstract

Keywords:
Cardiovascular diseaseElectronic medical recordsGoutRegister-based cohort study

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