Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and safety of estrogen therapy for prevention of osteoporosis in postmenopausal women.

Women's health (London, England)·2026
Same author

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4<sup>+</sup> lymphocytes.

British journal of clinical pharmacology·2026
Same author

A detailed review of pharmacokinetics/pharmacodynamics of progestogens in oral contraception.

Frontiers in endocrinology·2026
Same author

Sex steroid hormones, gonadotropins, and risk of testicular germ cell tumors: results from the STEED study.

Journal of the National Cancer Institute·2026
Same author

Long-term tamoxifen impacts the ovary but not preimplantation embryo development†.

Biology of reproduction·2025
Same author

Prevalence of endometrial hyperplasia and carcinoma in women with polycystic ovarian syndrome.

F&S reports·2025
Same journal

L-Arginine Improves Prenatal and Pre-pubertal Codeine-Induced Steroidogenesis Deregulation by Suppressing Oxidative Stress-Dependent Signaling in Male Wistar Rats.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

Discovery of 17-imidazo[1,2-a]pyridinyl-3α-hydroxy-5α-androstanes (17IPAs) as novel potent positive allosteric modulators of the GABA<sub>A</sub> receptor: Synthesis, in vitro and in silico studies.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

Androgen receptor as therapeutic indicator for LAR-positive triple-negative breast cancer: Preclinical and clinical assessment.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

The 24,25(OH)<sub>2</sub>D<sub>3</sub>-TLCD3B signaling complex and reproductive function in mice and men.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

Testosterone and epitestosterone differentially regulate UDP-glucuronosyltransferases (UGT) activity.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

Interferon-gamma-inducible protein-10 is associated to increased primary bile acids and fibrosis in primary sclerosing cholangitis.

The Journal of steroid biochemistry and molecular biology·2026
See all related articles

Related Experiment Video

Updated: Feb 20, 2026

Identification of a Murine Erythroblast Subpopulation Enriched in Enucleating Events by Multi-spectral Imaging Flow Cytometry
09:40

Identification of a Murine Erythroblast Subpopulation Enriched in Enucleating Events by Multi-spectral Imaging Flow Cytometry

Published on: June 6, 2014

13.0K

Estrobolome: Is there a missing link?

Giuseppe Benagiano1, Nicola Pluchino2, David Archer3

  • 1Faculty of Medicine and Dentistry, "Sapienza" University of Rome, Rome, Italy; Geneva Foundation for Medical Education and Research, Geneva, Switzerland.

The Journal of Steroid Biochemistry and Molecular Biology
|February 18, 2026
PubMed
Summary
This summary is machine-generated.

The gut microbiome

Keywords:
ArylsulfatasesBeta-glucuronidasesConjugated estrogensEstrobolomeGut microbiome

More Related Videos

Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

3.2K
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

13.0K

Related Experiment Videos

Last Updated: Feb 20, 2026

Identification of a Murine Erythroblast Subpopulation Enriched in Enucleating Events by Multi-spectral Imaging Flow Cytometry
09:40

Identification of a Murine Erythroblast Subpopulation Enriched in Enucleating Events by Multi-spectral Imaging Flow Cytometry

Published on: June 6, 2014

13.0K
Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

3.2K
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

13.0K

Area of Science:

  • Endocrinology
  • Microbiology
  • Gastroenterology

Background:

  • Estrogens are vital hormones influencing women's health, with disruptions linked to conditions like endometriosis.
  • The gut microbiome (GM) significantly impacts estrogen levels by metabolizing these hormones.
  • Microbial enzymes like β-glucuronidase (β-GLC) and steroid sulfatases (STS) play key roles in estrogen metabolism within the GM.

Purpose of the Study:

  • To investigate the role of gut microbial steroid sulfatases (STS) in estrogen metabolism.
  • To compare the significance of STS activity versus β-glucuronidase (β-GLC) activity in reactivating estrogens in the gut.
  • To understand the implications of microbial estrogen reactivation on enterohepatic recirculation and systemic estrogen levels.

Main Methods:

  • Analysis of microbial enzyme activity within the gut microbiome.
  • Investigation of estrogen sulfate conversion by bacterial enzymes.
  • Assessment of estrogen metabolism pathways involving β-GLC and STS.

Main Results:

  • Gut microbes possess steroid sulfatases (STS) capable of converting inactive estrogen sulfates into active estrogens.
  • Estrone sulfate (E1S), a major circulating estrogen, can be reactivated by microbial STS in the intestines.
  • This reactivation allows for enterohepatic recirculation of active estrogens, potentially influencing systemic estrogen levels.

Conclusions:

  • Gut microbial steroid sulfatases (STS) are crucial players in estrogen metabolism.
  • The activity of STS in reactivating estrogen sulfates may be more significant than β-GLC in regulating systemic estrogen concentrations.
  • Understanding the role of microbial STS is vital for comprehending estrogen-related conditions and hormonal balance.