Related Experiment Video
Updated: Feb 20, 2026

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis
Published on: August 15, 2025
The Effects of Plant Bioactive Polysaccharides on Metabolism-Related Indicators: an Umbrella Review of 33 Published
Xiaoshuang Hu1, Huiru Huang1, Wenxin Lu1
1Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
Background:
With the increasing prevalence of metabolic diseases, phytochemicals have shown great potential in the intervention of metabolic disorders. A number of studies have demonstrated that plant bioactive polysaccharides have significant effects in regulating metabolism. There is currently no comprehensive assessment of the evidence quality of studies of metabolism-related indicators.
Objectives:
This study aimed to demonstrate more credible associations between plant bioactive polysaccharides and various metabolism-related indicators by synthesizing evidence from systematic reviews and meta-analyses.
Methods:
We searched 5 databases for systematic reviews and meta-analyses of randomized controlled trials investigating the regulation of metabolic indicators by plant polysaccharides, with a total of 33 articles included, covering 111 metabolism-related indicators. Forest plots were used to summarize the indicators with significant and nonsignificant effects, and the methodological quality of the included articles and the quality of evidence were assessed based on the Assessment of Multiple Systematic Reviews version 2 and the Grading of Recommendations, Assessment, Development, and Evaluation.
Results:
The study covered 6 metabolism-related outcomes, including blood lipids (51%), blood glucose (22%), gastrointestinal function (8%), obesity (12%), and blood pressure and liver function-related outcomes (7%). The results indicated that plant polysaccharide consumption exerted a relatively significant effect on regulating blood lipids and blood glucose-related indicators and also demonstrated benefits in body weight control and gastrointestinal function improvement. However, it showed no significant effect on blood pressure control or liver function enhancement.
Conclusions:
The ability of plant polysaccharides to regulate carbohydrate and lipid metabolism suggests they hold promise as a preventive and therapeutic strategy for hyperlipidemia, hyperglycemia, and cardiovascular and gastrointestinal diseases. This trial was registered at PROSPERO as CRD42024528490 (https://www.crd.york.ac.uk/PROSPERO/myprospero).
More Related Videos
11:06Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
14:39Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Related Concept Videos
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Biosynthesis of Polysaccharides
Pharmacogenetics of Drug Metabolism: Overview
Overview of Metabolism
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion