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Multifrequency neuromagnetic activity and cognitive function in SeLECTS: network-based spectral alterations and
Xinyi Zhou1, Jing Lu1, Minghao Li1
1Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210024, China.
Neuroscience
|February 18, 2026
Summary
Children with self-limited epilepsy with centrotemporal spikes (SeLECTS) exhibit altered brainwave activity linked to cognitive deficits. These neurological differences are associated with specific gene expression patterns, offering insights into SeLECTS neurobiology.
Area of Science:
- Neuroscience
- Epileptology
- Cognitive Science
Background:
- Self-limited epilepsy with centrotemporal spikes (SeLECTS) is common in children.
- Cognitive vulnerabilities are observed in children with SeLECTS.
- Underlying neurophysiological mechanisms require elucidation.
Purpose of the Study:
- Investigate multifrequency resting-state neuromagnetic activity in children with SeLECTS.
- Explore associations between neurophysiology, cognition, and gene expression.
- Elucidate neurophysiological mechanisms of cognitive vulnerability in SeLECTS.
Main Methods:
- Magnetoencephalography (MEG) recordings in 59 children with SeLECTS and 30 controls.
- Spectral power calculation using Minimum Norm Estimation (MNE) and Welch's method across six frequency bands.
- Cognitive assessment (WISC-IV), Spearman's analysis, and spatial transcriptomic mapping (BrainSpan Atlas, GO, PPI networks).
Main Results:
- SeLECTS group showed enhanced theta and delta activity in frontoparietal control network (FPCN) and default mode network (DMN).
- SeLECTS group exhibited lower cognitive scores (except processing speed) compared to controls.
- FPCN theta power positively correlated with full-scale IQ (FSIQ) in SeLECTS; aberrant regions were genetically defined by an interconnected molecular module.
Conclusions:
- Spectral power analysis reveals frequency- and network-specific alterations in SeLECTS associated with cognitive performance.
- Neurophysiological signatures in SeLECTS brain regions are genetically enriched for mRNA splicing and metabolism modules.
- Findings suggest specific neurophysiological and genetic underpinnings for cognitive vulnerability in SeLECTS.
