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Optimising internet-based cognitive-behavioural therapy programme to prevent perinatal depression: a unified protocol
Rie Toyomoto1, Toshi A Furukawa2, Hisashi Noma3
1Department of Health Promotion and Behavioral Sciences, Kyoto University, Kyoto, Japan rie.toyomoto@gmail.com.
BMJ Open
|February 18, 2026
Summary
This study investigates internet-based cognitive-behavioural therapy (iCBT) for preventing perinatal depression. It aims to identify effective CBT skills and personalize treatment for pregnant women, improving maternal and infant outcomes.
Area of Science:
- Mental Health
- Psychiatry
- Perinatal Health
Background:
- Perinatal depression presents significant risks to mothers and infants.
- Effective prevention strategies are crucial due to its chronic nature.
- Internet-based cognitive-behavioural therapy (iCBT) shows promise, but specific skill efficacy and individual differences require further investigation.
Purpose of the Study:
- To confirm the effectiveness of iCBT for perinatal depression.
- To pinpoint active cognitive-behavioural therapy (CBT) skills beneficial for perinatal women.
- To explore how individual characteristics interact with CBT skills for personalized therapy.
Main Methods:
- Two harmonized multicentre randomized controlled trials involving 2400 pregnant women (10-20 weeks gestation).
- Participants receive psychoeducation (PE) followed by randomization to PE alone or one of five iCBT programs (e.g., behavioral activation, assertion training).
- Primary outcome: point prevalence of depression at 1 month postpartum using the Edinburgh Postnatal Depression Scale.
Main Results:
- Results are pending publication.
Conclusions:
- Results are pending publication.
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