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Updated: Feb 20, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Classic Hodgkin Lymphoma in the Older Adult: What's New?
Carrie Sha1, Sarah C Rutherford2
1Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue C-1283 New York, NY 10065, USA.
Abstract:
Outcomes for older patients with classic Hodgkin lymphoma (cHL) are improving with the inclusion of novel agents into frontline therapy. The sequential brentuximab vedotin (BV) and doxorubicin, vinblastine, dacarbazine (AVD) regimen was standard of care for many older adults with cHL until the checkpoint inhibitor nivolumab (N) and AVD showed marked tolerability and efficacy compared with BV-AVD in the SWOG S1826 randomized, phase 3 clinical trial. Palliative regimens including BV-N are options for patients who are anthracycline-ineligible, and a forthcoming clinical trial will investigate the combination of gemcitabine and pembrolizumab in this population.
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