Visible-Light-Induced Carbamoylation for Synthesis of Dibenzo[b,f][1,4]oxazepine Carbonyl Amino Acid/Peptide Derivatives
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Updated: Feb 20, 2026

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Published on: November 9, 2019
Fan-Lin Zeng1, Jia-Nan Chen1, Yu-Xin Luo1
1Henan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou 450001, China.
Abstract:
Introducing amino acids/peptides onto the heterocycle via photocatalytic methods remains a significant challenge. A novel visible-light-driven carbamoylation approach was first developed, facilitating the efficient synthesis of dibenzo[b,f][1,4]oxazepine carbonyl amino acid/peptide derivatives (>40 examples, up to 98% yield) from DHP-tagged amino acids/peptides. This strategy offers mild reaction conditions, easy scale-up, broad substrate compatibility, environmental friendliness, simple operation, and high tolerance to diverse functional groups. In addition, it enables late-stage functionalization of amine-containing drugs/natural products/proteins.
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