Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 20, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
10:51

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

4.7K

Modelling adipose tissue-cancer crosstalk: a three-dimensional perspective.

Gabriele Strusi1, Caterina M Suelzu2, Justin Stebbing2

  • 1Department of Life Sciences, Anglia Ruskin University, Cambridge, UK. gabriele.strusi@aru.ac.uk.

Oncogene
|February 18, 2026
PubMed
Summary

Three-dimensional (3D) models offer advanced preclinical research tools by mimicking in vivo conditions. This review explores 3D systems for studying adipose tissue and cancer interactions, crucial for understanding obesity-related carcinogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cancer-associated fibroblasts as key regulators of lipid metabolism in the tumour microenvironment.

Oncogene·2026
Same author

The Impact of Study Size on COVID-19 Treatment Outcomes: A Meta-Epidemiological Study Comparing Large and Small Randomized Controlled Trials: A Systematic Review and Meta-Analyses.

Reviews in medical virology·2026
Same author

Botensilimab (Fc-enhanced anti-CTLA-4 antibody) plus balstilimab (anti-PD-1 antibody) in patients with treatment-refractory ovarian cancer.

Journal for immunotherapy of cancer·2025
Same author

Ten years of oncogene editorship: a decade of transformation.

Oncogene·2025
Same author

Beyond GLP-1s: The blueprint for systemic therapeutics that will reshape aging and medicine.

British journal of clinical pharmacology·2025
Same author

Salvage therapy with allogeneic invariant natural killer cells in a heavily pre-treated germ cell tumor.

Oncogene·2025

Area of Science:

  • Biomedical Engineering
  • Cancer Research
  • Endocrinology

Background:

  • Three-dimensional (3D) systems better mimic in vivo cell environments than traditional models.
  • Adipose tissue, once solely linked to energy storage, is now recognized as a dynamic endocrine organ influencing carcinogenesis.
  • Obesity-associated adipose tissue dysfunction is a significant risk factor for various cancers.

Purpose of the Study:

  • To review the current state of 3D model technologies for studying adipose tissue-cancer interactions.
  • To highlight the potential of 3D systems in preclinical research for cancer and obesity-related diseases.
  • To provide a perspective on adipose tissue-cancer crosstalk within advanced in vitro models.

Main Methods:

  • Literature review of existing 3D modeling platforms.

More Related Videos

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction
05:42

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

Published on: January 26, 2024

3.2K
A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk
09:04

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk

Published on: November 7, 2019

10.0K

Related Experiment Videos

Last Updated: Feb 20, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
10:51

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

4.7K
Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction
05:42

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

Published on: January 26, 2024

3.2K
A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk
09:04

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk

Published on: November 7, 2019

10.0K
  • Analysis of studies focusing on adipose tissue and cancer co-culture systems.
  • Evaluation of the biological relevance of 3D models in recapitulating in vivo conditions.

    • Main Results:

    • A gap exists in current 3D platforms for complex adipose tissue-cancer models.
    • 3D models show promise for investigating the crosstalk between adipose tissue and cancer.
    • These models offer a more biologically relevant approach to studying obesity-driven carcinogenesis.

    Conclusions:

    • Advanced 3D systems are essential for accurately modeling the in vivo tumor microenvironment.
    • There is a need for more sophisticated 3D models to study adipose tissue-cancer dynamics.
    • 3D technologies can significantly advance our understanding of obesity-related cancer development and progression.