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CRTAC1 inhibits progression of lung adenocarcinoma by suppressing integrin/FAK signaling

Yu Liu1, Yuanyuan Chang2,3, Haiying Li2

  • 1Department of Thoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Oncogene
|February 18, 2026
PubMed

Insights

CRTAC1 acts as a tumor suppressor in lung adenocarcinoma (LUAD) by inhibiting growth and metastasis. Lower CRTAC1 levels correlate with poor survival, suggesting it

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Lung adenocarcinoma (LUAD) is a major cause of cancer mortality globally.
  • Novel molecular targets are needed to improve LUAD treatment outcomes.
  • Understanding LUAD progression mechanisms is critical for developing new therapies.

Purpose of the Study:

  • To investigate the role of CRTAC1 as a tumor suppressor in LUAD.
  • To elucidate the molecular mechanisms by which CRTAC1 affects LUAD progression.
  • To evaluate CRTAC1 as a potential therapeutic target for LUAD.

Main Methods:

  • Analysis of CRTAC1 expression in LUAD tissues and correlation with patient survival.
  • In vitro and in vivo experiments to assess the functional impact of CRTAC1 on LUAD cell proliferation, migration, and invasion.
  • Investigation of the integrin/FAK signaling pathway in relation to CRTAC1 activity.

Main Results:

  • CRTAC1 expression is significantly downregulated in LUAD tissues.
  • Decreased CRTAC1 expression positively correlates with poorer patient survival.
  • CRTAC1 suppresses LUAD cell proliferation, migration, and invasion in vitro and in vivo.
  • CRTAC1 functions by inhibiting the integrin/FAK signaling pathway.

Conclusions:

  • CRTAC1 acts as a natural tumor suppressor in LUAD.
  • CRTAC1 inhibits LUAD progression by suppressing the integrin/FAK pathway.
  • CRTAC1 represents a promising therapeutic target for LUAD treatment strategies.

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