Hydrotropy in Pharmaceutical Analysis: Compilation, Evaluation, and Emerging Prospects of Hydrotropic Solvent-Based...

Area of Science:

• Analytical Chemistry
• Green Chemistry
• Pharmaceutical Sciences

Background:

• Hydrotropy offers an eco-friendly solubilization method for poorly soluble drugs.
• Hydrotropic agents in aqueous solutions enhance solubility via non-covalent interactions.
• Existing research focuses on formulation, with limited consolidated analysis of analytical applications.

Purpose of the Study:

• To comprehensively review and analyze analytical methods employing hydrotropic agents.
• To evaluate the trends, performance, and mechanistic basis of hydrotropy in analytical chemistry.
• To address challenges and future scope for hydrotropic systems in advanced analytical techniques.

Main Methods:

• Literature review of analytical methods (titrimetric, UV-Vis, HPLC) using hydrotropic agents over two decades.
• Analysis of commonly used hydrotropic agents like sodium benzoate, urea, and nicotinamide.
• Evaluation of mechanistic basis, trends, and performance metrics of hydrotropic analytical methods.

Main Results:

• Hydrotropic agents significantly enhance solubility and analytical accuracy.
• Methods using hydrotropy show improved sensitivity, reproducibility, and environmental compatibility.
• Common agents include sodium benzoate, sodium salicylate, urea, nicotinamide, and sodium citrate.

Conclusions:

• Hydrotropy provides a greener, safer, and economical alternative for pharmaceutical analysis.
• Hydrotropic systems offer improved analytical performance compared to traditional organic solvent methods.
• Future applications in advanced techniques like LC-MS and capillary electrophoresis are promising.