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Potential of (NH4)2Ce(PO4)2·H2O Phase for the Next Generation of Sunscreens: UV-Shielding Properties, Cytotoxicity
Taisiya O Kozlova1, Ekaterina D Sheichenko1,2, Daniil A Kozlov1
1Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119991, Russia.
Abstract:
Recently, it has been recognized that crystalline ceric phosphates are promising candidates for use in sunscreen cosmetics, as inorganic UV filters. The present paper provides deeper insights into the UV-shielding properties, biocompability, radical-scavenging properties and redox activity of the crystalline double ammonium ceric phosphate (NH4)2Ce(PO4)2·H2O. A strong correlation was established between conditions of hydrothermal synthesis and the functional characteristics of this compound. Suspensions containing (NH4)2Ce(PO4)2·H2O with an intermediate crystallite size of ∼70 nm had higher values of sun protection factor (SPF) and protection factor against UV-A radiation (UVAPF) than other cerium phosphates, and even than traditional UV filters─titanium and zinc oxides. It was shown that (NH4)2Ce(PO4)2·H2O particles at concentrations of 0.125-1.0 mg/mL, upon direct contact with human keratinocytes (HaCaT) or human mesenchymal stem cells, reduced their metabolic activity, while providing a photoprotective effect when exposed to ultraviolet radiation. The UV-shielding property of ammonium ceric phosphate at a concentration of 1.0 mg/mL preserved almost 100% of human mesenchymal stem cells. For the first time, the biochemical properties of (NH4)2Ce(PO4)2·H2O and another double phosphate, NH4Ce2(PO4)3, both containing cerium in a tetravalent state, were compared. Both phosphates demonstrated radical-scavenging properties in relation to alkylperoxyl radicals. (NH4)2Ce(PO4)2·H2O was found to have prooxidant activity toward hydrogen peroxide that was comparable with that of ceria nanoparticles, while NH4Ce2(PO4)3 demonstrated the lowest prooxidant action.
