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Updated: Feb 20, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Unraveling the Function of lncRNAs in Gliomas: Interaction With Signaling Pathways and Therapeutic Opportunities

Ahmed S Doghish1,2, Heba R Ghaiad3, Nourhan Elfar4,5

  • 1Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, Egypt.

Journal of Biochemical and Molecular Toxicology
|February 19, 2026
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key regulators in brain tumor development. Targeting lncRNA networks offers promising therapeutic strategies for brain tumors, advancing precision medicine.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genomics

Background:

  • Brain tumors present significant challenges in neuro-oncology due to aggressive behavior, treatment resistance, and molecular diversity.
  • Long non-coding RNAs (lncRNAs) are emerging as critical regulators of gene expression and cellular functions, influencing tumor biology.
  • Understanding lncRNA roles is crucial for developing novel brain tumor therapies.

Purpose of the Study:

  • To provide an in-depth review of lncRNA biogenesis, regulatory mechanisms, and functional roles in brain tumor development and progression.
  • To analyze the interplay between lncRNAs and key oncogenic signaling pathways in gliomas.
  • To identify gaps in current research and highlight emerging therapeutic strategies targeting lncRNAs.

Main Methods:

  • Systematic literature review of PubMed/MEDLINE, Scopus, and Web of Science databases (January 2010 - June 2025).
  • Analysis of lncRNA biogenesis pathways (canonical and non-canonical).
  • Examination of lncRNA functions as epigenetic regulators, ceRNAs, and structural scaffolds within the tumor microenvironment.

Main Results:

  • lncRNAs significantly influence oncogenic signaling pathways (PI3K/AKT, STAT3, Wnt/β-catenin, TGF-β), driving malignant transformation, invasion, stemness, and therapeutic resistance in gliomas.
  • lncRNAs act as epigenetic regulators, ceRNAs, and structural scaffolds, modulating the tumor microenvironment.
  • Key research gaps include understanding context-dependent therapeutic effects of lncRNAs.

Conclusions:

  • lncRNAs are pivotal in brain tumor pathogenesis and represent important therapeutic targets.
  • Targeting lncRNA-associated networks holds significant academic and translational potential for precision medicine in neuro-oncology.
  • Emerging therapies like antisense oligonucleotides and CRISPR-Cas systems offer a promising frontier for brain tumor treatment.
Keywords:
brain tumorepigenetic regulationgliomalong non‐coding RNAs (lncRNAs)oncogenic signaling pathwaystherapeutic intervention

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