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Gold@MnFe-Prussian Blue Analog Yolk@Shell Nanoparticles for Light-Triggered and pH-Sensitive Drug Release.

Shoaib Azeem1, Javier Alda-Gómez1, Roger Sanchis-Gual1

  • 1Instituto de Ciencia Molecular, Universitat De València, Paterna, Spain.

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Researchers developed novel gold/Prussian Blue yolk@shell nanostructures for advanced drug delivery. These nanostructures enhance drug loading and release, showing promise for combined chemo- and photothermal cancer therapy.

Keywords:
Prussian Blue Analogsdrug deliverygoldnanoparticlesyolk@shell

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Yolk@shell nanostructures offer unique advantages for biomedical applications.
  • Combining hollow nanoparticle properties with core@shell stability is crucial for drug delivery systems.

Purpose of the Study:

  • To synthesize multifunctional gold/manganese iron-Prussian Blue Analog (PBA) yolk@shell nanostructures.
  • To evaluate their potential for controlled drug delivery and combined chemo-photothermal therapy.

Main Methods:

  • A two-step synthesis involving core@shell formation and selective shell leaching.
  • Characterization of nanostructure architecture, drug loading, and release kinetics.
  • In vitro evaluation of cellular uptake and synergistic cytotoxicity.

Main Results:

  • Successful synthesis of Au@MnFe PBA yolk@shell nanostructures with a ~75 nm internal cavity.
  • Achieved ~50% doxorubicin loading efficiency and pH-dependent release.
  • Demonstrated enhanced drug release (~150%) under near-infrared (NIR) irradiation and synergistic cytotoxicity.

Conclusions:

  • Au@MnFe PBA yolk@shell nanostructures show significant potential for controlled drug delivery.
  • The system enables efficient photothermal conversion and combined therapeutic effects.
  • These nanostructures are promising platforms for advanced cancer treatment strategies.