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Large B-Cell Lymphoma Invading the Heart: Insights From Multimodality Imaging in a Young Woman
Rafael Sudário Vieira Toledo1, Maria Stanislavovna Tairova1, Camila Nicolela Martins1
1Faculdade de Ciências Médicas, Universidade Estadual de Campinas, São Paulo, Brazil.
JACC. Case Reports
|February 19, 2026
Summary
This case study highlights a rare aggressive diffuse large B-cell lymphoma (DLBCL) infiltrating the heart and pulmonary arteries. Multimodality imaging proved crucial for timely diagnosis and patient management.
Area of Science:
- Oncology
- Cardiology
- Radiology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Cardiac and mediastinal infiltration by DLBCL is rare.
- Accurate imaging is vital for diagnosing and managing cardiac lymphomas.
Purpose of the Study:
- To present a case of DLBCL with extensive cardiac and mediastinal involvement.
- To evaluate the role of multimodality imaging in diagnosing cardiac lymphoma.
- To emphasize the diagnostic utility of a combined imaging approach.
Main Methods:
- Case report of a young woman with suspected lymphoma.
- Noninvasive assessment using transthoracic echocardiography (TTE).
- Computed tomography (CT) and cardiac magnetic resonance (CMR) imaging.
Main Results:
- Demonstrated mediastinal, myocardial, pulmonary trunk, and coronary artery infiltration by DLBCL.
- Transthoracic echocardiography provided initial assessment.
- CT and CMR offered detailed characterization of tumor extent and cardiac involvement.
- Multimodality imaging facilitated precise diagnosis.
Conclusions:
- Multimodality imaging is valuable for diagnosing rare cardiac lymphomas.
- Each imaging modality contributes incrementally to diagnosis and management.
- Prompt diagnosis through imaging optimizes patient care for aggressive lymphomas.
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