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Large B-Cell Lymphoma Invading the Heart: Insights From Multimodality Imaging in a Young Woman

Rafael Sudário Vieira Toledo1, Maria Stanislavovna Tairova1, Camila Nicolela Martins1

  • 1Faculdade de Ciências Médicas, Universidade Estadual de Campinas, São Paulo, Brazil.

JACC. Case Reports
|February 19, 2026
PubMed

We report a case of a young woman who presented with a rapidly growing and aggressive diffuse large B-cell lymphoma with mediastinal and myocardial infiltration and involvement of the pulmonary trunk and coronary arteries. A noninvasive multimodality imaging assessment was performed with transthoracic echocardiography, computed tomography, and cardiac magnetic resonance. Although this approach may allow for a precise and timely characterization of myocardial infiltration and thus demonstrate therapeutic implications, large B-cell lymphoma has been rarely documented using contemporary multimodality imaging techniques. This report underscores the value of a multimodality diagnostic strategy, illustrating the incremental contribution of each routinely available imaging modality to achieve prompt diagnosis and optimize patient management.

Keywords:
computed tomographyechocardiographyimaginglymphomamagnetic resonancemetastasismyocardium infiltration

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