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Updated: Feb 20, 2026

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
Published on: July 10, 2017
[Childhood and adolescent adversity : from toxic stress to clinical practice]
Caroline Heiniger1, Charlotte Reith2, Clothilde Hamion3
1Service de pédiatrie générale, Département femme-mère-enfant, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Insights
Adverse childhood experiences (ACEs) can negatively impact health and behavior long-term. However, protective factors and support systems, including healthcare interventions, can significantly mitigate these harmful effects.
Area of Science:
- Childhood development
- Public health
- Neuroscience
Abstract:
Adverse childhood experiences are common and have a lasting impact on physical and mental health, as well as on risky behaviors. The mechanisms involved include chronic activation of the stress response, as well as brain, immune, and epigenetic alterations that contribute to long-term vulnerability. However, these effects are not irreversible: the presence of protective factors can mitigate their consequences. Healthcare workers play a crucial role in strengthening parental and social support while promoting positive childhood experiences, all of which are key determinants of long-term health and development.
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