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Related Concept Videos

Cystic Fibrosis: Management01:24

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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
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Related Experiment Video

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Development of a Cystic Fibrosis Weight Management Programme:  protocol for a co-design study.

Joanne Barrett1,2, Anne Elizabeth Topping3, Nikos Ntoumanis2,4

  • 1West Midlands Adult CF Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, England, B9 5SS, UK.

NIHR Open Research
|February 19, 2026
PubMed
Summary
This summary is machine-generated.

Highly effective modulator therapies improve cystic fibrosis (CF) health but cause weight gain. A co-developed CF-specific weight management program (CF WMP) will complement existing programs for adults with CF who are overweight or obese.

Keywords:
NHS digital weight management programbehaviour change wheelco-designcystic fibrosisperson-based approach

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Area of Science:

  • Medical Science
  • Public Health
  • Behavioral Science

Background:

  • Highly effective modulator therapies (HEMT) have improved health outcomes for adults with cystic fibrosis (CF).
  • HEMT use is associated with significant weight gain, leading to over 30% of adults with CF being overweight or obese.
  • Current weight management programs may not adequately address the specific needs of individuals with CF.

Purpose of the Study:

  • To outline the co-development of a cystic fibrosis-specific weight management program (CF WMP).
  • To ensure the CF WMP complements the NHS digital Weight Management Programme (WMP) for adults with CF who are overweight or obese.
  • To address the unique dietary and physical activity needs of people with CF experiencing weight gain.

Main Methods:

  • Utilizing a three-phase Person Based Approach (PBA): planning, co-designing, and optimizing.
  • Conducting mixed-methods research with people with CF who are overweight/obese (PwCFow/ob) and healthcare professionals to identify barriers and facilitators.
  • Employing participatory workshops for co-design and think-aloud interviews for iterative refinement of the CF WMP.

Main Results:

  • Identification of barriers and facilitators to healthy eating and physical activity in PwCFow/ob.
  • Development of guiding principles to inform the co-design of an engaging, acceptable, and motivating CF WMP.
  • Iterative refinement of the CF WMP based on feedback from PwCFow/ob.

Conclusions:

  • The co-developed CF WMP aims to enhance the usability of the NHS digital WMP for adults with CF.
  • The program is designed to meet the evolving health needs of adults with CF since the introduction of HEMT.
  • This tailored approach seeks to improve weight management outcomes for this specific population.