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Gliosarcoma: A Case Series and Comprehensive Literature Review
Harvey Misael Aguilar Mora1, Laura Karina Barrera Roman2, Gervith Reyes Soto3
1Department of Neurosurgery, Hospital Juárez de México, Mexico City, MEX.
Cureus
|February 19, 2026
Summary
This study details three gliosarcoma cases, a rare brain tumor with glial and mesenchymal parts. Despite aggressive multimodal treatment, these patients experienced disease progression, highlighting the tumor's challenging prognosis.
Area of Science:
- Neuro-oncology
- Pathology
- Neurosurgery
Background:
- Gliosarcoma is a rare primary central nervous system neoplasm.
- It is characterized by a biphasic histological architecture combining glial and mesenchymal elements.
- Understanding its clinical presentation, imaging, and pathology is crucial.

