Related Experiment Video
Updated: Feb 20, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Characterization and Management of a Rare Recurrent Pediatric Papillary Hemangioma
Hannah Soltani1, Sophia G Allison1, Narain Reddy2
1From the Feinberg School of Medicine, Northwestern University, Chicago, IL.
None:
Papillary hemangiomas (PHs) are rare, benign vascular tumors, typically described in adults. Few pediatric cases have been reported, and recurrence is uncommon. We presented a unique case of PH in a 15-month-old male patient with recurrence after surgical excision. The patient presented with a left cheek lesion present since birth, which had grown proportionally with his development. Initial ultrasound demonstrated a superficial, hypoechoic, heterogeneous lesion with increased vascularity. Surgical excision was performed, and pathology demonstrated large, thin-walled, irregular vascular channels with arborizing fronds, eosinophilic hyaline globules, and CD31+ endothelial cells, findings consistent with PH. Four months postoperatively, imaging revealed recurrence. Re-excision was performed, including branching structures initially thought to be nutrient vessels. Nitro paste was applied postoperatively due to concern for the thin overlying skin. PH is rarely congenital and can be misdiagnosed as other vascular anomalies. This case emphasized the importance of recognizing branching structures that may represent lesion extensions to optimize complete excision. Multidisciplinary management is recommended for diagnosis, treatment planning, and follow-up.
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

