Supersonic Cryogenic Jet Delivery of Polynucleotides Compared With Manual Intradermal Injection

Area of Science:

• Aesthetic medicine
• Dermatology
• Drug delivery systems

Background:

• Exploring transdermal drug delivery devices as an alternative to traditional polynucleotide (PN) injections.
• Highlighting potential benefits such as reduced pain and faster recovery.
• Investigating noncontact PN delivery methods.

Purpose of the Study:

• To compare the efficacy of transdermal drug delivery devices versus traditional PN injections for skin treatments.
• To evaluate patient satisfaction and clinical outcomes between the two delivery methods.

Main Methods:

• A clinical trial involving 4 participants comparing transdermal delivery (TargetCool) and manual intradermal injections on opposing sides of the face.
• Outcomes assessed via standardized photography, skin analysis, and patient-reported scales (Global Aesthetic Improvement Scale, visual analog scale).

Main Results:

• Transdermal delivery demonstrated comparable skin improvement to PN injections.
• The transdermal method offered significant advantages in terms of reduced pain and shorter recovery times.
• Ultrasound measurements indicated similar effectiveness, with a slight edge for transdermal devices in improving skin density.

Conclusions:

• Transdermal drug delivery devices represent a safe and effective alternative to conventional PN injections.
• These devices provide comparable aesthetic outcomes with enhanced patient comfort and convenience.