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Sarcoglaucone A, a novel sarsolenane-related diterpenoid from the soft coral Sarcophyton glaucum
Yue-Wen Chuang1,2, Atallah F Ahmed3,4, Hsiao-Ling Chung1,2
1Department of Marine Biotechnology and Resources, National Sun Yat-sen University Kaohsiung 804201 Taiwan sheu@mail.nsysu.edu.tw.
Abstract:
Two sarsolenane-type diterpenoids, including a known compound, dihydrosarsolenone (1), and a novel metabolite, sarcoglaucone A (2), were isolated from the soft coral Sarcophyton glaucum, collected off the coast of Taiwan. The absolute configuration of dihydrosarsolenone (1) was determined by single-crystal X-ray difraction (SC-XRD) analysis for the first time in this study. The structure of sarsolenane 2 was established on the basis of spectroscopic analysis and further confirmed by SC-XRD analysis. One aspect of the stereochemistry of the known sarsolenanes 1 (dihydrosarsolenone) and methyl dihydrosarsolenoneate was revised. Sarsolenane 1 was found to exhibit activity in enhancing alkaline phosphatase (ALP) activity in human osteoblast-like cells (MG63).
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