Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.6K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.6K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

1.1K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.1K
Antibiotic Selection00:57

Antibiotic Selection

60.4K
Overview
60.4K
Antimicrobial Proteins01:23

Antimicrobial Proteins

14.7K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.7K
Vaccinations01:51

Vaccinations

52.0K
Overview
52.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vaccines and antimicrobial resistance: from science to policy-summary and outcomes.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same author

Immunologic and biophysical features of the BNT162b2 JN.1 and KP.2 adapted COVID-19 vaccines.

Nature communications·2025
Same author

A Phase 3B, Open-Label Study to Evaluate the Immunogenicity and Safety of the Quadrivalent Meningococcal Nimenrix<sup>®</sup> Vaccine When Given to Healthy Infants at 3 and 12 Months of Age.

Infectious diseases and therapy·2025
Same author

Preclinical characterization of the Omicron XBB.1.5-adapted BNT162b2 COVID-19 vaccine.

NPJ vaccines·2024
Same author

Preclinical immunogenicity and safety of hemagglutinin-encoding modRNA influenza vaccines.

NPJ vaccines·2024
Same author

Calibration of a serum reference standard for Group B streptococcal polysaccharide conjugate vaccine development using surface plasmon resonance.

NPJ vaccines·2023

Related Experiment Video

Updated: Feb 20, 2026

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

1.9K

Vaccines against antimicrobial resistance.

Annaliesa S Anderson1

  • 1Vaccines, Pfizer Inc, Pearl River, New York, NY10965, USA.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|February 19, 2026
PubMed
Summary

Antimicrobial resistance (AMR) is a growing global threat. Vaccines are crucial for preventing infections, reducing antibiotic use, and combating AMR, with new vaccines for Clostridioides difficile and group B Streptococcus on the horizon.

Keywords:
Clostridioides difficileKlebsiella pneumoniaeSalmonella TyphiStreptococcus pneumoniaeRSVantibioticsgroup Bstreptococcusinfluenzaresistancevaccination

More Related Videos

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.1K
Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
06:54

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics

Published on: July 19, 2024

1.7K

Related Experiment Videos

Last Updated: Feb 20, 2026

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

1.9K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.1K
Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
06:54

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics

Published on: July 19, 2024

1.7K

Area of Science:

  • Infectious Diseases
  • Immunology
  • Public Health

Background:

  • Antimicrobial resistance (AMR) poses a significant global clinical and economic threat, projected to cause 10 million deaths annually by 2050.
  • The escalating crisis necessitates sustainable prevention strategies to curb the spread of drug-resistant infections in both community and healthcare settings.

Purpose of the Study:

  • To review existing vaccines effective in reducing the burden of AMR.
  • To highlight the critical role of vaccine development in tackling AMR.
  • To focus on the urgent need for vaccines against Clostridioides difficile and group B Streptococcus.

Main Methods:

  • Literature review of existing bacterial and viral vaccines.
  • Analysis of vaccine impact on infection rates and antibiotic consumption.
  • Discussion of the pipeline for novel vaccines targeting AMR pathogens.

Main Results:

  • Several existing vaccines demonstrate efficacy in mitigating the impact of AMR.
  • Vaccines prevent infections, thereby reducing the need for antimicrobial interventions.
  • Promising vaccine candidates for Clostridioides difficile and group B Streptococcus are nearing development.

Conclusions:

  • Vaccines are a vital component of the strategy to combat antimicrobial resistance.
  • Continued development and implementation of vaccines are essential for global health security.
  • Targeted vaccine development for pathogens like Clostridioides difficile and group B Streptococcus holds significant promise for reducing AMR.