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Co-Ablation System for Pain Management in Bone Metastases: Retrospective Exploratory Study.

Hang Yuan1, Wei-Li Xia1, Ho-Young Song1

  • 1The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.

JMIR Cancer
|February 19, 2026
PubMed
Summary

A novel co-ablation system effectively reduced pain in patients with bone metastases, improving quality of life with no observed adverse events. This innovative treatment offers a promising option for managing metastatic bone pain.

Keywords:
bone metastasesco-ablation systemcryoablationpain managementthermal ablation

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Area of Science:

  • Oncology
  • Pain Management
  • Interventional Radiology

Background:

  • Bone metastasis is a common and debilitating complication of cancer.
  • It significantly impacts patient mobility, causes severe pain, and reduces quality of life.

Purpose of the Study:

  • To evaluate the pain-relieving effects and safety of a combined hyperthermic and cryoablation system for bone metastases.

Main Methods:

  • Retrospective analysis of nine patients with painful bone metastases treated with co-ablation.
  • Pain assessed via Numerical Rating Scale (NRS), functional status via Karnofsky Performance Status (KPS).
  • Evaluated technical success, adverse events, analgesic use, and pain response over 12 weeks.

Main Results:

  • All procedures were technically successful with no adverse events.
  • Median NRS pain scores decreased from 5 to 2 at 12 weeks.
  • 88.9% of patients experienced meaningful pain reduction by week 4, with improved KPS scores and reduced analgesic needs.

Conclusions:

  • The co-ablation system is a feasible and safe option for managing painful bone metastases.
  • It demonstrated significant short-term pain relief and functional improvement.
  • No ablation-related adverse events were reported, indicating a favorable safety profile.