Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Interfacial Electrochemical Methods: Overview

Interfacial Electrochemical Methods: Overview

Interfacial electrochemical methods focus on the phenomena occurring at the boundary between an electrode and a solution, as opposed to bulk methods that concentrate on the solution's overall properties. These interfacial methods are classified as either static or dynamic based on the presence of a nonzero current in the electrochemical cell and the consistency of analyte concentrations. Static methods, such as potentiometry, measure the cell's potential without any significant current...

Electrophoresis: Overview

Electrophoresis: Overview

Electrophoresis is a powerful analytical separation technique that relies on the differential migration of charged species when subjected to an electric field. The core strength of electrophoresis lies in its ability to separate high-molecular-weight species in complex mixtures. It has found widespread use in biochemistry, molecular biology, and analytical chemistry, allowing the separation of compounds like amino acids, nucleotides, carbohydrates, and proteins with excellent resolution.
There...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Role of Surgery on the Treatment of Primary Pulmonary Sarcomas and Pulmonary Sarcomatoid Carcinoma.

Annals of surgical oncology·2026

Same author

Announcing the 2026 <i>ACS Nano</i> Lectureship and <i>ACS Nano</i> Impact Award Laureates.

ACS nano·2026

Same author

Announcing the 2026 <i>ACS Nano</i> Lectureship and <i>ACS Nano</i> Impact Award Laureates.

ACS nano·2026

Same author

Announcing the 2026 <i>ACS Nano</i> Lectureship and <i>ACS Nano</i> Impact Award Laureates.

ACS nano·2026

Same author

Announcing the 2026 <i>ACS Nano</i> Lectureship and <i>ACS Nano</i> Impact Award Laureates.

ACS nano·2026

Same author

Risk prediction of <i>Helicobacter pylori</i> strains across Correa's cascade via intelligent analysis of genome-wide SNPs.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

On-Cell Detection of Polysaccharide One-Bond <sup>1</sup>J<sub>CH</sub> Couplings by Proton-Detected Solid-State NMR.

Journal of the American Chemical Society·2026

Same journal

Correction to "Unraveling the Effects of Fe Incorporation on High-Performance Water-Splitting Photoanodes".

Journal of the American Chemical Society·2026

Same journal

Proximity-Driven Protein Ligation Beyond the Concentration Limit.

Journal of the American Chemical Society·2026

Same journal

GraPhAI: Neural Networks for Solving Centrosymmetric Crystal Structures.

Journal of the American Chemical Society·2026

Same journal

Probing Stage Transition Kinetics in Li-Graphite Intercalation Compounds by Time-Resolved In Situ Solid-State NMR via <sup>13</sup>C Labeling.

Journal of the American Chemical Society·2026

Same journal

Dynamic Covalent Programming at DNA Base-Pairing Interfaces.

Journal of the American Chemical Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 1, 2026

Real-Time Metabolic Detection in Living Cells Using Hyperpolarized 13C NMR

Real-Time Metabolic Detection in Living Cells Using Hyperpolarized ¹³C NMR

Published on: July 8, 2025

Electrochemomics Profiling Metabolic Dynamics in Biofluids.

Jianwu Wang^1,2, Huarong Xia², Chenyan Huang³

¹Institute for Digital Molecular Analytics and Science (IDMxS), Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore.

Journal of the American Chemical Society

|February 19, 2026

Summary

This summary is machine-generated.

We developed an electrochemomics (EC-omics) approach for disease diagnosis using biofluid analysis. This method accurately detects periodontitis from saliva, outperforming traditional biomarker analysis.

More Related Videos

Metabolic Analysis of Drosophila melanogaster Larval and Adult Brains

Metabolic Analysis of Drosophila melanogaster Larval and Adult Brains

Published on: August 7, 2018

Sheathless Capillary Electrophoresis–Mass Spectrometry for Metabolic Profiling of Biological Samples

Sheathless Capillary Electrophoresis–Mass Spectrometry for Metabolic Profiling of Biological Samples

Published on: October 1, 2016

Related Experiment Videos

Last Updated: Apr 1, 2026

Real-Time Metabolic Detection in Living Cells Using Hyperpolarized 13C NMR

Real-Time Metabolic Detection in Living Cells Using Hyperpolarized ¹³C NMR

Published on: July 8, 2025

Metabolic Analysis of Drosophila melanogaster Larval and Adult Brains

Metabolic Analysis of Drosophila melanogaster Larval and Adult Brains

Published on: August 7, 2018

Sheathless Capillary Electrophoresis–Mass Spectrometry for Metabolic Profiling of Biological Samples

Sheathless Capillary Electrophoresis–Mass Spectrometry for Metabolic Profiling of Biological Samples

Published on: October 1, 2016

Area of Science:

Electrochemistry
Biomolecular analysis
Diagnostic technology

Background:

Conventional electrochemical sensing relies on predefined biomarkers, facing challenges with biofluid complexity and calibration biases.
Significant electrochemical information at biofluid interfaces remains untapped for comprehensive metabolic profiling.

Purpose of the Study:

To introduce an electrochemomics (EC-omics) approach for comprehensive profiling of biomolecule dynamics in biofluids during disease onset.
To develop and validate a portable electrochemical platform for unbiased biofluid analysis.

Main Methods:

Customized a portable electrochemical profiling platform utilizing carbon nanotube/bacterial cellulose (CNT/BC) electrodes for high sensitivity and low noise.
Applied the EC-omics platform to analyze saliva for periodontitis diagnosis, creating an EC-omics database.
Integrated intelligent algorithms with the EC-omics data for disease discrimination.

Main Results:

The EC-omics platform accurately discriminated periodontitis in saliva samples with 93% accuracy.
This performance surpassed untargeted nuclear magnetic resonance (89%) and traditional periodontitis biomarkers (70%).
Demonstrated EC-omics feasibility in human urine and mouse serum, indicating broad applicability.

Conclusions:

EC-omics offers a holistic and unbiased method for analyzing biofluid electrochemical properties for disease diagnosis.
The developed platform shows significant potential for expanding the understanding of metabolic networks and developing novel decentralized healthcare diagnostic tools.