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Updated: Jul 5, 2026

A Technique to Simultaneously Visualize Virus-Specific CD8+ T Cells and Virus-Infected Cells In situ
Published on: August 13, 2009
High-resolution imaging techniques to interrogate virus-host interactions
Isabel Amaya1, Chelsey C Spriggs1,2,3
1Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Abstract:
Viruses are obligate parasites that rely extensively on host cellular machinery to complete their life cycles. Therefore, examining the fundamental nature behind how viruses interact with their hosts can teach us more about the pathogenesis of these microbes while also contributing to our overall understanding of essential cell biological processes. In a 2021 mSphere of Influence article, the use of live-cell imaging to uncover a unique mechanism of viral assembly was discussed. In this Full Circle review, we highlight the high-resolution imaging techniques currently revolutionizing virology research and discuss how they can be utilized to advance our ability to identify and interrogate novel virus-host interactions.
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