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Updated: Jun 16, 2026

Automated Gel Size Selection to Improve the Quality of Next-generation Sequencing Libraries Prepared from Environmental Water Samples

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Published on: April 17, 2015

Exploring Size-Controlled Exciton Evolution Using DNA Libraries.

Jeffrey Gorman^1,2, Sarah Orsborne¹, Peter Budden¹

¹Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, United Kingdom.

Journal of the American Chemical Society

|February 19, 2026

Summary

This summary is machine-generated.

Researchers developed a DNA-based method to rapidly assemble multiple light-absorbing molecules (chromophores). This DNA-directed assembly enables efficient screening of charge separation and electronic delocalization for new electronic materials.

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Spectroscopic Super-resolution Imaging of DNA Molecules using Intrinsic Contrast

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Published on: March 6, 2026

Area of Science:

Molecular electronics
Supramolecular chemistry
Organic semiconductors

Background:

Investigating multichromophore systems traditionally requires synthesizing model covalent dimers.
Molecular semiconductors like porphyrins and perylene diimides (PDIs) are crucial for organic electronics.
Nucleic acid libraries offer a platform for rapid screening of complex molecular phenomena.

Purpose of the Study:

To develop a DNA-directed assembly method for creating multichromophore systems.
To enable rapid screening of charge separation and electronic delocalization.
To create tailored electronic properties through sequence-programmed hybridization.

Main Methods:

Integrating porphyrins and perylene diimides (PDIs) into DNA sequences.
Utilizing base-sequence programmed hybridization for nearest-neighbor assembly.
Computational prescreening for π-stacking to predict orbital overlap and exchange energy.

Main Results:

Successfully assembled up to five π-conjugated chromophores using DNA.
Demonstrated charge separation and electronic delocalization in the assembled systems.
Achieved on-demand dimer and multimer production within hours.
Validated computational prescreening for optimizing charge transfer.

Conclusions:

DNA-directed assembly provides a modular platform for bespoke chromophore architectures.
This method allows stoichiometric control and ordering of chromophores.
Enables rapid development and screening of multichromophore systems for electronic applications.