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Ubiquitin-Specific Protease 10: A New Target in Tumor Immune Escape

Jingjing Huang1, Ning Li2, Jiangang Sun3

  • 1Department of General Surgery, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.

Cancer Control : Journal of the Moffitt Cancer Center
|February 19, 2026
PubMed

Insights

Ubiquitin-specific protease 10 (USP10) stabilizes immune checkpoints, promoting tumor immune escape. Targeting USP10 may enhance cancer therapies by modulating the tumor immune microenvironment.

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Tumor immune escape presents a significant challenge in cancer treatment.
  • Ubiquitin-specific protease 10 (USP10) is a deubiquitinating enzyme involved in tumor development.
  • USP10's role in tumor immune escape is an emerging area of research.

Purpose of the Study:

  • To review the structural and functional characteristics of USP10.
  • To elaborate on USP10's biological function in tumor development and immune escape.
  • To provide insights into USP10's role in regulating immune checkpoints and the tumor immune microenvironment.

Main Methods:

  • Literature review focusing on USP10's function in cancer.
  • Analysis of USP10's involvement in deubiquitination processes.
  • Examination of USP10's impact on immune checkpoints and cellular immunity.

Main Results:

  • USP10 stabilizes key immune checkpoints, thereby reducing tumor cell immunogenicity.
  • USP10 actively promotes tumor immune escape by influencing the tumor microenvironment.
  • USP10 affects the function of immune cells within the tumor microenvironment.

Conclusions:

  • USP10 plays a critical role in facilitating tumor immune escape.
  • Regulating USP10 expression offers a potential strategy to enhance existing cancer therapies.
  • Understanding USP10 mechanisms is crucial for developing novel anti-cancer treatments.
Keywords:
immune checkpoint blockadeinhibitorstargetstherapytumors

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