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Shaping the Future of HER2-Directed Therapy in Biliary Tract Cancer
Orla M Fitzpatrick1, James J Harding1,2
1Memorial Sloan Kettering Cancer Center , New York, New York.
None:
This commentary on a retrospective study of patients with HER2-positive biliary tract cancer highlights the importance of reflex and validated HER2 testing criteria, the discordance of next-generation sequencing and HER2 IHC, the potential prognostic and predictive role of HER2, and the necessity to define HER2 therapy resistance mechanisms. See related article by Lee et al., p. 1745.
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