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Published on: April 9, 2012
Test Performance of Expired Malaria Rapid Diagnostic Tests: A Pilot Diagnostic Accuracy Study Conducted in Western
Ronnie Ndizeye1, Annika K Gunderson2,3, Emmanuel Baguma1
1Department of Community Health, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Abstract:
We evaluated the diagnostic agreement of expired malaria rapid diagnostic tests (mRDTs) with nonexpired mRDTs in a clinical setting in western Uganda. Expired mRDTs (SD Bioline Ag Pf/Pan and First Response Ag pLDH/HRP2) were administered to each participant in parallel with a nonexpired mRDT serving as the reference. Of 200 participants, 21 (10.5%) tested positive and 179 (89.5%) tested negative for malaria. All tests up to 9 months postexpiration were valid and consistent with reference mRDTs. All mRDTs 10-12 months postexpiration were invalid. These preliminary findings support further research into the use of expired mRDTs in resource-limited settings.
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