Related Experiment Video
Updated: Feb 21, 2026
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Factors Associated With PICU Admission In Children With Multisystem Inflammatory Syndrome (MIS-C): An Observational
Aida Borgi1, Amal Miraoui1, Rahma Guedri2
1University of Tunis of EL-Manar- Faculty of Medicine of Tunis, Children's Hospital Bechir Hamza of Tunis, Pediatric intensive care unit, Tunis, Tunisia.
Insights
Cardiac dysfunction is the primary risk factor for Pediatric Intensive Care Unit (PICU) admission in children with severe Multisystem Inflammatory Syndrome in Children (MIS-C). Early identification of cardiac issues is crucial for managing MIS-C patients.
Area of Science:
- Pediatric critical care medicine
- Infectious diseases
- Pediatric cardiology
Background:
- Multisystem Inflammatory Syndrome in Children (MIS-C) is a serious condition following COVID-19.
- Identifying factors predicting severe MIS-C requiring Pediatric Intensive Care Unit (PICU) admission is vital.
Purpose of the Study:
- To investigate factors associated with PICU admission in children diagnosed with severe MIS-C.
- To identify predictors of critical illness in pediatric MIS-C patients.
Main Methods:
- Observational cohort study conducted in Tunisia from July 2020 to May 2021.
- Included 45 children with severe MIS-C, analyzing clinical data and laboratory markers.
- Statistical analysis to determine factors associated with PICU admission.
Main Results:
- Sixteen patients (35%) required PICU admission.
- Higher frequencies of respiratory distress, shock, cardiac dysfunction, elevated CRP, and troponin were observed in PICU patients.
- Cardiac dysfunction was the sole independent predictor of PICU admission (aOR = 12.8, p=0.002).
Conclusions:
- Cardiac dysfunction is the only independent risk factor for PICU admission in children with MIS-C.
- This finding highlights the importance of cardiac monitoring in severe MIS-C cases.
Purpose:
To investigate factors associated with Pediatric Intensive Care Unit (PICU) admission in children with severe MIS-C.
Methods:
We conducted an observational cohort study between July 1, 2020, and May 31, 2021, in the only pediatric hospital in Tunisia.
Results:
A total of 45 children (33 males) with no recent history of COVID-19 infection were included. Mean age was 7±3.2 years. Sixteen patients (35%) required PICU admission. There was no significant difference in mean age of patients with and without PICU admission (7.5±2.7 vs. 6.76±3.46 years; p=0.4). The frequency of respiratory distress (p=0.001), shock (p=0.001), cardiac dysfunction (p=0.003), mean CRP (p=0.001), and median troponin (p=0.003) were significantly higher in patients with PICU admission than in those without. The independent predictive factor for PICU admission was cardiac dysfunction; adjusted Odds Ratio (aOR) = 12.8, 95% CI = (2.1-76.4), p=0.002.
Conclusion:
The only independent risk factor for PICU admission in patients with MIS-C was cardiac dysfunction.
More Related Videos
08:51Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
10:38Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
Published on: January 16, 2019
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:18Factors Affecting Illness
For instance, risk factors are connected to illness,...
01:29Endocarditis IV: Nursing Management