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Related Experiment Video

Updated: Feb 21, 2026

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Factors Associated With PICU Admission In Children With Multisystem Inflammatory Syndrome (MIS-C): An Observational

Aida Borgi1, Amal Miraoui1, Rahma Guedri2

  • 1University of Tunis of EL-Manar- Faculty of Medicine of Tunis, Children's Hospital Bechir Hamza of Tunis, Pediatric intensive care unit, Tunis, Tunisia.

La Tunisie Medicale
|February 19, 2026
PubMed
Summary

Cardiac dysfunction is the primary risk factor for Pediatric Intensive Care Unit (PICU) admission in children with severe Multisystem Inflammatory Syndrome in Children (MIS-C). Early identification of cardiac issues is crucial for managing MIS-C patients.

Keywords:
AfricaCOVID-19childrenintensive caremultisystem inflammatory diseasenorthern

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Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Pediatric cardiology

Background:

  • Multisystem Inflammatory Syndrome in Children (MIS-C) is a serious condition following COVID-19.
  • Identifying factors predicting severe MIS-C requiring Pediatric Intensive Care Unit (PICU) admission is vital.

Purpose of the Study:

  • To investigate factors associated with PICU admission in children diagnosed with severe MIS-C.
  • To identify predictors of critical illness in pediatric MIS-C patients.

Main Methods:

  • Observational cohort study conducted in Tunisia from July 2020 to May 2021.
  • Included 45 children with severe MIS-C, analyzing clinical data and laboratory markers.
  • Statistical analysis to determine factors associated with PICU admission.

Main Results:

  • Sixteen patients (35%) required PICU admission.
  • Higher frequencies of respiratory distress, shock, cardiac dysfunction, elevated CRP, and troponin were observed in PICU patients.
  • Cardiac dysfunction was the sole independent predictor of PICU admission (aOR = 12.8, p=0.002).

Conclusions:

  • Cardiac dysfunction is the only independent risk factor for PICU admission in children with MIS-C.
  • This finding highlights the importance of cardiac monitoring in severe MIS-C cases.