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Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing
Published on: August 25, 2018
Artificial intelligence for microbiology and microbiome research
Xu-Wen Wang1, Tong Wang2, Yang-Yu Liu1
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Abstract:
Advancements in artificial intelligence (AI) have transformed many scientific fields, with microbiology and microbiome research now experiencing significant breakthroughs through machine-learning applications. This review provides a comprehensive overview of AI-driven approaches tailored for microbiology and microbiome studies, emphasizing both technical advancements and biological insights. We first introduce foundational AI techniques and offer guidance on choosing between traditional machine-learning and sophisticated deep-learning methods based on specific research goals. The primary section on application scenarios spans diverse research areas from taxonomic profiling, functional annotation and prediction, microbe-X interactions, microbial ecology, metabolic modeling, precision nutrition, and clinical microbiology to prevention and therapeutics. Finally, we discuss challenges in this field and highlight some recent breakthroughs. Together, this review underscores AI's transformative role in microbiology and microbiome research, paving the way for innovative methodologies and applications that enhance our understanding of microbial life and its impact on our planet and our health.
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