Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[<sup>18</sup>F]FDG PET/CT Radiomics for Predicting Pathological Risk Subtypes of Thymic Epithelial Tumors: A Bicentric Study.

Cancers·2026
Same author

Interventional radiology in the management of complications after pancreatic surgery: a single-center experience.

Abdominal radiology (New York)·2026
Same author

Measuring Atrioventricular Valve Regurgitation in Fontan Patients Using Cardiac MRI and the Association with Clinical Outcomes: A FORCE Study.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance·2026
Same author

Role and Characteristic of Multidisciplinarity in Hepatocellular Carcinoma Management and Care Pathway Certification: Bottom-Up Approach of the MDT Project in Italy.

Oncology and therapy·2026
Same author

Multicenter comparison of hybrid and Norwood procedures in patients with Fontan circulation.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Cone-beam computed tomography-guided navigation-assisted irreversible electroporation for recurrent cervical lymph node metastasis: technical feasibility and early experience.

Diagnostic and interventional radiology (Ankara, Turkey)·2026

Related Experiment Video

Updated: Jun 29, 2026

Thermal Ablation for the Treatment of Abdominal Tumors
07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

35.8K

Percutaneous Cryoablation for Sternal Bone Metastases: A Retrospective Study.

Laura Olivieri1, Giuseppina Pacella2, Elva Vergantino1

  • 1Unit of Diagnostic Imaging and Interventional Radiology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.

Journal of Vascular and Interventional Radiology : JVIR
|February 19, 2026
PubMed
Summary

Percutaneous cryoablation offers a less invasive option for treating sternal metastases. This study found it safe and effective, significantly reducing pain and achieving local control in most patients.

More Related Videos

Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy
04:10

Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy

Published on: July 19, 2024

1.6K
A New Technique for Treating Low-risk Prostate Cancer&#8212;Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

1.1K

Related Experiment Videos

Last Updated: Jun 29, 2026

Thermal Ablation for the Treatment of Abdominal Tumors
07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

35.8K
Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy
04:10

Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy

Published on: July 19, 2024

1.6K
A New Technique for Treating Low-risk Prostate Cancer&#8212;Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

1.1K

Area of Science:

  • Oncology
  • Interventional Radiology
  • Pain Management

Background:

  • Sternal metastases present unique challenges due to proximity to mediastinal structures and severe pain.
  • Percutaneous cryoablation is explored as a minimally invasive palliative treatment option.

Purpose of the Study:

  • To evaluate the safety and efficacy of percutaneous cryoablation for sternal metastases.
  • To assess pain reduction and local control rates following the procedure.

Main Methods:

  • Retrospective review of 14 patients with sternal metastases (primary tumors: breast, lung, renal cell carcinoma, myxoid liposarcoma).
  • Procedures performed between 2017-2025 using Cone-Beam CT (CBCT) or CT guidance with ultrasound assistance.
  • Pain assessed using Numeric Rating Scale (NRS) and Visual Analog Scale (VAS); local control evaluated via imaging.

Main Results:

  • Significant pain reduction reported by 93% of patients (mean NRS decreased from 7.31 to 3.15; mean VAS from 6.64 to 3.21).
  • Statistically significant pain reduction (p<0.000001) for both NRS and VAS.
  • Local control achieved in both cases treated with curative intent.

Conclusions:

  • Percutaneous cryoablation demonstrates safety and effectiveness for palliation of painful sternal metastases.
  • The technique offers a promising minimally invasive approach for managing this challenging condition.
  • Further evaluation of percutaneous cryoablation for sternal metastases is warranted.