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Antipsychotic Medication Preferences: A Large-Scale Survey.

Babet N Wezenberg¹, Jara Bouws^1,2, Marieke van der Pluijm^1,2

¹Department of Psychiatry, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.

Pharmacopsychiatry

|February 19, 2026

Summary

Patient preferences for antipsychotic medications vary significantly. Understanding these individual needs, including desired symptom efficacy and acceptable side effects, is crucial for improving treatment adherence and trust in shared decision-making.

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Area of Science:

Psychiatry
Pharmacology
Patient-Centered Care

Background:

Antipsychotic medications are vital for treating psychotic disorders.
Large-scale studies on individual patient preferences for these medications are scarce.
Understanding patient perspectives is key to optimizing treatment outcomes.

Purpose of the Study:

To explore variations in patient perspectives on antipsychotic treatment.
To identify key factors influencing patient preferences regarding efficacy, side effects, and administration routes.
To investigate demographic and medication-related differences in these preferences.

Main Methods:

Data collected from 8,743 individuals with psychotic episodes using the online Personal Antipsychotic Choice Index questionnaire.
Assessed preferences for treatment effectiveness, side effects, and administration routes.
Analyzed responses using non-parametric tests, comparing by sex, age, and D2-receptor affinity of medication.

Main Results:

Psychotic symptom efficacy was the highest priority (75.4%), followed by cognitive (61.9%) and depressive (49.5%) symptom efficacy.
Extrapyramidal symptoms (73.2%) and weight gain (68.0%) were the least acceptable side effects.
Daily tablets were the most preferred administration route (91.0%), while patient preferences varied based on sex, age, and medication's D2-receptor affinity.

Conclusions:

Significant variations exist in patient preferences for antipsychotic medications.
Incorporating patient preferences into shared decision-making can enhance trust and treatment adherence.
Tailoring treatment based on individual needs is essential for effective management of psychotic disorders.