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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...

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Exosomal miRNA Analysis in Non-small Cell Lung Cancer (NSCLC) Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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Circulating proteomic landscape of lung function.

Mikyeong Lee1, Thomas R Austin2, Yura Lee3

  • 1Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA mikyeong.lee@nih.gov.

The European Respiratory Journal
|February 19, 2026
PubMed
Summary
This summary is machine-generated.

This study identified over 1000 proteins linked to lung function in adults, offering new insights into respiratory disease. Many of these novel protein associations could lead to better diagnostic biomarkers and treatments.

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Area of Science:

  • Pulmonary Medicine
  • Proteomics
  • Genetics

Background:

  • Genetic and epigenetic studies have identified genes related to lung function.
  • Proteomics offers direct insights into pathophysiologic processes but remains underexplored in lung function research.

Purpose of the Study:

  • To identify circulating proteins associated with lung function.
  • To explore novel protein biomarkers for respiratory conditions.

Main Methods:

  • Investigated spirometry parameters (FEV1, FVC, FEV1/FVC) in relation to 4693 circulating proteins across five cohorts (20,823 adults).
  • Used robust linear regression adjusting for confounders and meta-analysis via inverse-variance weighting.
  • Validated associations in the UK Biobank using the Olink 3K platform.

Main Results:

  • 1055 proteins significantly associated with lung function traits (p<1×10^-5) in a multi-ancestry population.
  • Enriched pathways involved inflammation and organismal injury; STAT3 and EGFR identified as potential orchestrators.
  • 411 protein associations validated; 179 related to COPD; preliminary causal evidence for 34 proteins via Mendelian randomisation.
  • 89% of associated proteins were novel in relation to lung function.

Conclusions:

  • Identified novel protein-lung function associations.
  • Findings may improve understanding of lung disease pathogenesis.
  • Potential for discovery of circulating biomarkers and development of new management strategies for respiratory conditions.