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Rosuvastatin calcium: A comprehensive profile.

Amany A Aboomeirah¹, Ahmed Maher Abdeldayem¹, Hassan Mohamed El-Said Azzazy¹

¹Department of Chemistry, School of Sciences and Engineering, The American University in Cairo, New Cairo, Egypt.

Profiles of Drug Substances, Excipients, and Related Methodology

|February 19, 2026

Summary

Rosuvastatin calcium is a statin drug that effectively lowers high cholesterol when lifestyle changes are insufficient. This review details its properties, synthesis, thermal analysis, and analytical methods for quality control.

Keywords:

HPLC Hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor NMR Pharmacokinetics Rosuvastatin calcium Thermal analysis UV spectroscopy

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Area of Science:

Pharmacology
Medicinal Chemistry
Analytical Chemistry

Background:

Hypercholesterolemia management often requires pharmacologic intervention when lifestyle modifications fail.
Rosuvastatin calcium (Ros-Ca) represents a significant development in the statin drug class for cholesterol reduction.
Genetic factors and other health conditions can necessitate pharmacological treatment for high cholesterol.

Purpose of the Study:

To provide a comprehensive review of Rosuvastatin calcium.
To detail the physiochemical characteristics, synthesis, and thermal analysis of Ros-Ca.
To explore analytical methodologies for both quantitative and qualitative assessment of Ros-Ca.

Main Methods:

Literature review of Rosuvastatin calcium.
Analysis of physiochemical properties.
Examination of synthesis pathways.
Review of thermal analysis techniques.
Survey of analytical methods for Ros-Ca quantification and identification.

Main Results:

Rosuvastatin calcium effectively inhibits hepatic cholesterol synthesis.
Detailed physiochemical, synthesis, and thermal data are presented.
A range of analytical techniques are suitable for Ros-Ca analysis.

Conclusions:

Rosuvastatin calcium is a key therapeutic agent for managing hypercholesterolemia.
Understanding its characteristics and analytical methods is crucial for quality assurance.
This review serves as a valuable resource for researchers and pharmaceutical professionals.