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Advancements in technology for developing recombinant live biotherapeutics.

Jyoti Verma1, Deepjyoti Paul2

  • 1Integrated Science Lab, Umeå University, Umeå, Sweden.

Progress in Molecular Biology and Translational Science
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PubMed
Summary

Engineered live biotherapeutics (rLBPs) show promise for treating diseases by restoring microbial balance and modulating immunity. Continued innovation and clinical evaluation are crucial for their advancement as next-generation therapeutics.

Keywords:
Artificial intelligence (AI)BioengineeringMachine learning (ML)MultiomicsRecombinant live biotherapeutics (rLBPs)Synthetic biology

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Area of Science:

  • Microbiology
  • Biotechnology
  • Synthetic Biology

Background:

  • Growing evidence highlights the crucial role of microbes in human health.
  • Engineered live biotherapeutics (rLBPs) offer a novel approach to target disease mechanisms directly.
  • rLBPs are microbial species engineered to restore balance, modulate immunity, and treat diseases.

Purpose of the Study:

  • To review recent advances in the development of recombinant live biotherapeutics (rLBPs).
  • To highlight opportunities and challenges in advancing rLBPs for clinical translation.
  • To emphasize the need for innovation and rigorous evaluation of rLBPs.

Main Methods:

  • Leveraging synthetic biology and genetic engineering for rLBP design.
  • Utilizing multi-omics and artificial intelligence/machine learning (AI/ML) for enhanced efficacy.
  • Developing strategies for scalability, safety, and clinical application.

Main Results:

  • rLBPs are being designed for improved efficacy and regulatory acceptance.
  • Early studies demonstrate promising therapeutic potential for various diseases.
  • Significant challenges in scalability, safety, and clinical application persist.

Conclusions:

  • rLBPs represent a promising frontier in next-generation therapeutics.
  • Continued innovation, rigorous clinical evaluation, and translational strategies are essential.
  • Advancing rLBPs requires addressing current hurdles to establish their therapeutic role.