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Updated: Feb 21, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Microbiota-derived metabolites in intestinal immune disorders

Hisako Kayama1, Kiyoshi Takeda2

  • 1Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka, Japan; Institute for Advanced Co-Creation Studies, University of Osaka, Suita, Osaka, Japan; WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka, Japan.

Progress in Molecular Biology and Translational Science
|February 19, 2026
PubMed
Summary

The gut microbiota influences inflammatory bowel disease (IBD) by altering immune responses and gut barrier function. Understanding these interactions is key to developing new IBD therapies.

Keywords:
Bioactive lipidsCrohn’s diseaseG protein-coupled receptorInflammatory bowel diseaseMicrobial cyclic dinucleotidesNOD2STINGToll-like receptorUlcerative colitis

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