Related Experiment Video

Updated: Feb 21, 2026

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.9K

Prognostic Value of Left Ventricular Standardized Mechanical Dispersion Derived From Cardiac Magnetic Resonance

Sisi Zhu1, Liumei Li1, Xiaoxia Liu1

  • 1Department of Radiology, Affiliated Hospital 2 of Nantong University, Nantong 226001, PR China (S.Z, L.L., X.L., D.W., J.J., T.W.).

Academic Radiology
|February 19, 2026
PubMed

Insights

Standardized left ventricular mechanical dispersion (sLVMD) predicts major adverse cardiovascular events (MACEs) in dilated cardiomyopathy (DCM) patients. This cardiac imaging metric offers valuable prognostic insights beyond traditional risk factors.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Biomedical Engineering

Background:

  • Dilated cardiomyopathy (DCM) is a significant cause of heart failure and sudden cardiac death.
  • Accurate prognostic assessment in DCM is crucial for guiding clinical management and improving patient outcomes.
  • Current risk stratification models may not fully capture the complex pathophysiology of DCM.

Purpose of the Study:

  • To determine the prognostic capability of standardized left ventricular mechanical dispersion (sLVMD) for major adverse cardiovascular events (MACEs) in DCM patients.
  • To evaluate the added predictive value of sLVMD to existing risk models for MACEs.
  • To explore the incremental prognostic information provided by sLVMD in DCM.

Main Methods:

  • A cohort of DCM patients undergoing cardiac magnetic resonance (CMR) imaging was analyzed.
  • Left ventricular mechanical dispersion (LVMD) was quantified using CMR feature tracking in radial, circumferential, and longitudinal directions.
  • Standardized LVMD (sLVMD) was calculated by normalizing LVMD to cardiac cycle duration; MACEs included cardiac death, heart failure hospitalization, and malignant arrhythmia.

Main Results:

  • Elevated sLVMD levels were significantly associated with a higher incidence of MACEs during follow-up.
  • Multifactorial Cox regression identified sLVMD (sRMD, sCMD, sLMD) as an independent predictor of MACEs.
  • The predictive model incorporating sLVMD demonstrated a significant improvement in C-statistic compared to models without sLVMD.

Conclusions:

  • sLVMD, assessed via CMR, is a robust independent predictor of MACEs in patients with DCM.
  • sLVMD provides significant incremental prognostic information, enhancing risk assessment in DCM.
  • This imaging biomarker holds potential for improved clinical decision-making in DCM management.
Abstract

Keywords:
Cardiac magnetic resonanceDilated cardiomyopathyMajor adverse cardiac eventsMechanical dispersion

More Related Videos

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

7.3K
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.7K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
622
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
545
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
300
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
626