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Characteristics and Transmission Dynamics of Global Travel-Related Mpox Cases Caused by Clade Ib Monkeypox Virus
Abstract:
We examined 89 travel-related clade Ib monkeypox virus cases detected in 33 countries during August 2024-July 2025. Most cases were approximately men; about one third led to secondary transmission. Secondary transmission risk was highest among sexual, then household, contacts. Those groups should be the focus of response strategies and interventions.
Insights
Travel-related monkeypox virus (MPXV) clade Ib cases were analyzed. The study highlights high secondary transmission risk among sexual and household contacts, informing targeted public health interventions.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Monkeypox virus (MPXV) poses a global health threat.
- Clade Ib MPXV has been associated with recent outbreaks.
- Understanding transmission dynamics is crucial for control.
Purpose of the Study:
- To analyze travel-related Clade Ib MPXV cases.
- To identify risk factors for secondary transmission.
- To inform targeted public health response strategies.
Main Methods:
- Retrospective analysis of 89 travel-related MPXV cases.
- Data collected from 33 countries between August 2024 and July 2025.
- Assessment of secondary transmission events and contact types.
Main Results:
- 89 travel-related Clade Ib MPXV cases identified across 33 countries.
- Majority of cases identified in men.
- Approximately one-third of cases resulted in secondary transmission.
- Highest secondary transmission risk observed in sexual contacts, followed by household contacts.
Conclusions:
- Sexual and household contacts are key populations for MPXV transmission.
- Public health interventions should prioritize these high-risk groups.
- Targeted strategies are essential for controlling Clade Ib MPXV spread.
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