Characteristics and Transmission Dynamics of Global Travel-Related Mpox Cases Caused by Clade Ib Monkeypox Virus

PubMed

Insights

Travel-related monkeypox virus (MPXV) clade Ib cases were analyzed. The study highlights high secondary transmission risk among sexual and household contacts, informing targeted public health interventions.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • Monkeypox virus (MPXV) poses a global health threat.
  • Clade Ib MPXV has been associated with recent outbreaks.
  • Understanding transmission dynamics is crucial for control.

Purpose of the Study:

  • To analyze travel-related Clade Ib MPXV cases.
  • To identify risk factors for secondary transmission.
  • To inform targeted public health response strategies.

Main Methods:

  • Retrospective analysis of 89 travel-related MPXV cases.
  • Data collected from 33 countries between August 2024 and July 2025.
  • Assessment of secondary transmission events and contact types.

Main Results:

  • 89 travel-related Clade Ib MPXV cases identified across 33 countries.
  • Majority of cases identified in men.
  • Approximately one-third of cases resulted in secondary transmission.
  • Highest secondary transmission risk observed in sexual contacts, followed by household contacts.

Conclusions:

  • Sexual and household contacts are key populations for MPXV transmission.
  • Public health interventions should prioritize these high-risk groups.
  • Targeted strategies are essential for controlling Clade Ib MPXV spread.

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