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A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
04:47

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

Antibody-modification of measles "in vitro" infection

J J Gould, J D Almeida

    Journal of Medical Virology
    |January 1, 1977
    PubMed

    Insights

    Measles virus infection can lead to subacute sclerosing panencephalitis (SSPE). This study shows that antibodies alter measles virus in cell cultures, potentially explaining how measles causes chronic SSPE.

    Area of Science:

    • Virology
    • Neuroscience
    • Immunology

    Background:

    • Measles virus is implicated in subacute sclerosing panencephalitis (SSPE), a chronic neurological disease.
    • The precise mechanisms linking acute measles infection to chronic SSPE remain poorly understood.

    Purpose of the Study:

    • To investigate the in vitro effects of antibody presence on measles virus behavior.
    • To explore potential mechanisms for measles virus-induced chronic conditions like SSPE.

    Main Methods:

    • Culturing Vero cells infected with the MV 30 strain of measles virus.
    • Incubating infected cells in the presence of multivalent antibody.
    • Observing viral antigen distribution and viral properties after antibody removal.

    Main Results:

    • Multivalent antibody induced redistribution of viral antigens within infected Vero cells.
    • The altered measles virus properties persisted even after the removal of antiserum.
    • These in vitro changes suggest a potential mechanism for chronic measles virus persistence.

    Conclusions:

    • Antibody-mediated changes in measles virus in vitro may mirror in vivo processes.
    • This could provide a model for understanding measles encephalitis in hamsters and human SSPE.

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