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Acute Severe Hepatitis B Virus Infection in Previously Vaccinated Patient during Acalabrutinib Treatment
Emerging Infectious Diseases
|February 20, 2026
Abstract:
We describe acute severe hepatitis B virus (HBV) infection with liver failure requiring transplantation in a patient in Poland treated with acalabrutinib. The patient was fully vaccinated against HBV and had adequate HBV antibody titers and no HBV exposure documented before therapy. Differential diagnoses for jaundice should consider HBV in patients receiving acalabrutunib.

